Holden made her screen debut in 1997, playing the supporting role of Vicky in the low-budget drama The Last Time I Committed
Suicide. She had parts in a range of comedies throughout the late 1990s and early 2000s, such as In & Out (1997), EDtv (1999)
Drop Dead Gorgeous (1999), Sugar & Spice (2001), and The Hot Chick (2002). Next, she starred in the horror films Wishcraft (2002)
Dead End (2003), Dark Reel (2008), Lovely Molly (2011), and Always Watching: A Marble Hornets Story (2015). Other notable credits
include American Gun (2002), How to Deal (2003), Special (2006), All the Days Before Tomorrow (2007), In a World... (2013), and the
crime thriller Other Monsters (2022).